TABLE 4

HRs (95% CI) of developing diabetes comparing quartiles of IL-18 levels

Quartile of IL-18
1234
Median (lower, upper limit) (pg/ml)80.09 (4.9, 116.7)145.18 (116.8, 173.5)205.04 (173.6, 244.6)322.08 (244.7, 8,792.4)P value for trend
n (nondiabetic/diabetic)424/95429/108417/146428/178
Model 11.01.13 (0.84–1.52)1.57 (1.18–2.09)1.96 (1.49–2.58)<0.001
Model 21.01.18 (0.87–1.60)1.64 (1.22–2.20)1.93 (1.45–2.56)<0.001
Model 31.01.10 (0.78–1.57)1.62 (1.16–2.25)1.73 (1.25–2.40)<0.001
Model 41.01.10 (0.78–1.57)1.61 (1.16–2.24)1.73 (1.25–2.40)<0.001
  • Model 1, crude; model 2, adjusted for age, sex, and survey; model 3, adjusted for factors in model 2 + BMI, systolic blood pressure, ratio of total cholesterol to HDL cholesterol, physical activity, alcohol intake, smoking status, and parental history of diabetes; and model 4, adjusted for factors in model 3 + CRP and IL-6.