TABLE 2

Multipoint linkage analysis of four genome scans for type 1 diabetes (P < 0.01)

ChromosomePosition (cM)Closest markerNominal LODNominal P valueλSGenome-wide P value*
2q31-q33192D2S21673.349.0 × 10−51.190.016
3p13-p1498D3S12611.528.2 × 10−31.150.649
6p2147TNFA116.304.9 × 10−523.35<1.0 × 10−4
6q2180D6S28322.397.0 × 10−71.56
9q33-q34150D9S2602.201.5 × 10−31.130.191
10p14-q1161D10S14263.211.2 × 10−41.120.021
11p152D11S9221.873.4 × 10−31.160.371
12q14-q1281D12S3751.665.8 × 10−31.100.528
16p12-q11.156D16S31311.883.3 × 10−31.170.363
16q22-q24108D16S5042.644.9 × 10−41.190.075
19p13.3-p13.225INSR1.923.0 × 10−31.150.338
  • *

    * All genome-wide empiric P values are based on simulations of 10,000 replicates.

  • Empirical P value determined by simulation and estimated correlation of IBD between HLA and IDDM15, not genome-wide (see research design and methods); empirical P < 1.0 × 10−4.