Multipoint linkage analysis of four genome scans for type 1 diabetes (P < 0.01)
| Chromosome | Position (cM) | Closest marker | Nominal LOD | Nominal P value | λS | Genome-wide P value* |
|---|---|---|---|---|---|---|
| 2q31-q33 | 192 | D2S2167 | 3.34 | 9.0 × 10−5 | 1.19 | 0.016 |
| 3p13-p14 | 98 | D3S1261 | 1.52 | 8.2 × 10−3 | 1.15 | 0.649 |
| 6p21 | 47 | TNFA | 116.30 | 4.9 × 10−52 | 3.35 | <1.0 × 10−4 |
| 6q21 | 80 | D6S283 | 22.39 | 7.0 × 10−7 | 1.56 | † |
| 9q33-q34 | 150 | D9S260 | 2.20 | 1.5 × 10−3 | 1.13 | 0.191 |
| 10p14-q11 | 61 | D10S1426 | 3.21 | 1.2 × 10−4 | 1.12 | 0.021 |
| 11p15 | 2 | D11S922 | 1.87 | 3.4 × 10−3 | 1.16 | 0.371 |
| 12q14-q12 | 81 | D12S375 | 1.66 | 5.8 × 10−3 | 1.10 | 0.528 |
| 16p12-q11.1 | 56 | D16S3131 | 1.88 | 3.3 × 10−3 | 1.17 | 0.363 |
| 16q22-q24 | 108 | D16S504 | 2.64 | 4.9 × 10−4 | 1.19 | 0.075 |
| 19p13.3-p13.2 | 25 | INSR | 1.92 | 3.0 × 10−3 | 1.15 | 0.338 |
* All genome-wide empiric P values are based on simulations of 10,000 replicates.
† Empirical P value determined by simulation and estimated correlation of IBD between HLA and IDDM15, not genome-wide (see research design and methods); empirical P < 1.0 × 10−4.