TABLE 2

Baseline characteristics of IRAS subjects free of NCEP metabolic syndrome and diabetes at baseline, stratified by NCEP metabolic syndrome status at the follow-up examination

VariableNCEP metabolic syndrome status at follow-up examination
All subjectsExcluding former and heavy drinkers
No metabolic syndromeMetabolic syndromeNo metabolic syndromeMetabolic syndrome
n506127412100
Age (years)52.4 ± 8.653.2 ± 8.154.0 ± 8.853.0 ± 8.0
BMI (kg/m2)26.3 ± 4.029.0 ± 4.8*26.3 ± 4.028.9 ± 4.8*
Waist circumference (cm)85.5 ± 10.491.8 ± 10.6*85.1 ± 10.291.4 ± 10.5*
Fasting glucose (mg/dl)95.1 ± 9.5100.0 ± 10.7*95.1 ± 9.599.3 ± 10.5*
2-h glucose (mg/dl)114.9 ± 31.2129.0 ± 32.4*113.8 ± 30.9129.1 ± 32.7*
Fasting insulin (pmol/l)10 (7–15)14 (10–18)10 (8–15)14 (10–18)*
HDL (mg/dl)51.3 ± 15.844.4 ± 12.2*51.5 ± 16.644.5 ± 12.8*
Triglyceride (mg/dl)93 (69–128.5)117 (88–154)94 (69–130)119 (90–154)*
Systolic blood pressure (mmHg)122.8 ± 18.0130.6 ± 18.2*122.2 ± 17.3129.6 ± 17.7*
Diastolic blood pressure (mmHg)76.7 ± 9.480.0 ± 9.476.4 ± 9.179.6 ± 9.3
Si ×10−4 (min−1 · UU−1 · ml−1)2.2 (1.3–3.6)1.5 (1.0–2.3)*2.2 (1.3–3.6)1.5 (0.9–2.2)*
AIR (pmol · ml−1 · min−1)393.1 (181.0–670.6)367.3 (143.5–664.6)395.5 (181.4–677.5)401.1 (166.7–720.4)
CRP (mg/l)1.3 (0.6–2.4)1.8 (0.9–4.2)1.3 (0.6–2.4)1.7 (0.8–4.5)§
AST (units/l)20 (16–25)21 (16–27)20 (16–25)20.5 (16–27)
ALT (units/l)15 (10–21)17 (11–25)§15 (10–20)17 (11–25)
AST-to-ALT ratio1.3 (1.0–1.8)1.2 (0.9–1.6)§1.4 (1.0–1.8)1.2 (0.9–1.6)§
ALK (units/l)59 (48–71)62 (52–75)§58 (48.5–71)62 (52–75)
Total bilirubin (mg/dl)0.5 (0.3–0.6)0.5 (0.4–0.7)0.5 (0.3–0.6)0.5 (0.4–0.6)
Sex (% male/female)82.4/78.017.6/22.083.2/78.316.8/21.8
Ethnicity (% NHW/AA/HA)78.7/81.4/80.021.3/18.6/20.078.2/83.3/80.421.8/16.7/19.7
Glucose tolerance (% IGT)84.7/65.415.3/34.6*85.3/64.814.8/35.2*
Alcohol consumption category80.3/78.119.7/21.9
  • Data are means ± SD or, for skewed variables or proportions, median (interquartile range). Differences assessed using t test or Wilcoxon tests (for continuous variables) or χ2 tests (for categorical variables).

  • * P < 0.0001,

  • P < 0.001,

  • P < 0.01,

  • § P < 0.05 vs. no metabolic syndrome at follow-up.

  • Alcohol categories: never, very little, ≤0.5 drinks/day, 0.5 to <1 drink/day, and 1 to <3 drinks/day vs. ex-drinker and ≥3 drinks/day. AA, African Americans; HA, Hispanic American; NHW, non-Hispanic white.