TABLE 6

Multivariate logistic regression analysis of markers of liver injury and risk of incident components of NCEP metabolic syndrome in IRAS subjects

Independent variableUnitFast hyperglycemia (112/742)*Abdominal obesity (96/619)*High triglyceride (98/611)*Low HDL (72/442)*Hypertension (142/466)*
ALTSD of log1.46 (1.16–1.82)1.18 (0.93–1.50)1.24 (0.99–1.55)1.26 (0.97–1.63)1.09 (0.87–1.36)
Q4 vs. Q13.12 (1.65–5.91)1.29 (0.66–2.53)1.73 (0.92–3.26)1.61 (0.76–3.40)0.91 (0.48–1.71)
AST-to-ALT ratioSD of log0.67 (0.52–0.86)0.87 (0.68–1.12)0.86 (0.68–1.09)0.89 (0.67–1.17)1.01 (0.81–1.26)
Q4 vs. Q10.48 (0.25–0.91)§1.06 (0.53–2.12)0.71 (0.37–1.35)0.69 (0.33–1.45)0.99 (0.52–1.87)
ALKSD of log1.28 (1.03–1.60)§1.15 (0.91–1.46)1.28 (1.01–1.61)§1.44 (1.11–1.88)1.05 (0.84–1.30)
Q4 vs. Q12.10 (1.11–3.98)§1.43 (0.71–2.86)2.41 (1.17–4.97)§1.89 (0.88–4.06)1.01 (0.55–1.84)
CRPSD of log1.40 (1.13–1.73)1.49 (1.19–1.86)1.15 (0.91–1.42)1.16 (0.89–1.51)1.44 (1.16–1.78)
Q4 vs. Q12.38 (1.27–4.46)3.25 (1.59–6.66)1.23 (0.65–2.32)1.61 (0.77–3.38)2.47 (1.33–4.56)
  • Data are OR (95% CI) from separate models. Subjects were free of diabetes and the outcome of interest at baseline but not necessarily free of metabolic syndrome. Sample sizes therefore vary in different analyses. OR adjusted for age, sex, ethnicity, clinical center, and alcohol intake; ORs in rows indicated by SD refer to risk of incident metabolic syndrome associated with a 1-SD difference in the independent variable (see Table 3). ORs in rows indicated by Q4 vs. Q1 refer to the rate of incident metabolic syndrome among those in the 4th quartile of the independent variable compared with those in the lowest quartile.

  • * Events/total at risk.

  • P < 0.01,

  • P < 0.001,

  • § P < 0.05.