TABLE 1

DCCT baseline and close-out characteristics of participants versus nonparticipants active as of year 10 of the EDIC study

DCCT baselineSkin biopsy study
ParticipantsNonparticipantsP
n2111,143
DCCT baseline
    Age (years)28 ± 727 ± 70.006
    Women48480.979
    Diabetes duration (years)5.0 ± 4.15.7 ± 4.10.013
    Stimulated C-peptide (pmol/ml)0.12 ± 0.110.11 ± 0.120.376
    Insulin dosage (units/kg)0.63 ± 0.230.67 ± 0.250.008
    A1C8.8 ± 1.78.9 ± 1.60.922
    Systolic blood pressure (mmHg)116 ± 11114 ± 120.011
    Diastolic blood pressure (mmHg)73 ± 972 ± 90.268
    Triglycerides (mmol) (now in mg/dl)81 ± 5280 ± 470.825
    HDL cholesterol (mmol) (now in mg/dl)51 ± 1250 ± 120.634
    LDL cholesterol (mmol) (now in mg/dl)111 ± 30109 ± 290.409
    No retinopathy (10/10)5749
    Microaneurisms only <(20/20)2532
    Mild nonproliferative diabetic retinopathy <(30/30)1010
    Moderate nonproliferative diabetic retinopathy <(45/45)780.145
    Albuminuria (mg/24 h)15 ± 1416 ± 200.225
    Creatinine clearance (ml/min)131 ± 32128 ± 280.248
    AER >40 mg/day4.35.10.619
    Presence of clinical neuropathy8.15.80.201
DCCT close out (EDIC baseline)
    DCCT mean A1C8.0 ± 1.68.2 ± 1.40.400
    Systolic blood pressure (mmHg)117 ± 11116 ± 120.670
    Diastolic blood pressure (mmHg)75 ± 974 ± 90.192
    Triglycerides (mmol) (now in mg/dl)79 ± 4287 ± 530.017
    HDL cholesterol (mmol) (now in mg/dl)51 ± 1351 ± 130.944
    LDL cholesterol (mmol) (now in mg/dl)111 ± 29114 ± 290.098
    Severe nonproliferative diabetic retinopathy or worse (53/<53+)1.95.50.032
    Laser (focal or scatter)2.85.50.105
    Albuminuria (mg/24 h)25 ± 10249 ± 3290.047
    AER >40 mg/dl9.59.80.877
  • Data are means ± SD or percent.