TABLE 3

Summary of multiple multivariate logistic regressions for retinopathy

Covariate effects from multiple models	df	χ²	P value	R²
Unadjusted effect
DCCT mean A1C	1	34.3	<0.0001	0.142
EDIC study mean A1C	1	40.5	<0.0001	0.168
Furosine, CML, pentosidine, fluorescence, acid/pepsin soluble	6	62.2	<0.0001	0.258
Pentosidine, fluorescence, acid/pepsin soluble	4	21.8	0.0002	0.090
Furosine, CML	2	59.4	<0.0001	0.246
Furosine	1	52.2	<0.0001	0.216
CML	1	27.7	<0.0001	0.115
Adjusted effect
DCCT mean A1C effect adjusted for
Furosine, CML	1	0.0	0.9874	0.000
Furosine	1	0.4	0.5430	0.001
CML	1	17.4	<0.0001	0.072
EDIC study mean A1C effect adjusted for
Furosine, CML	1	26.0	<0.0001	0.108
Furosine	1	24.6	<0.0001	0.102
CML	1	43.4	<0.0001	0.180
Furosine, CML effect adjusted for
Pentosidine, fluorescence, acid/pepsin soluble	2	46.3	<0.0001	0.192
DCCT mean A1C	2	32.7	<0.0001	0.136
EDIC study mean A1C	2	45.9	<0.0001	0.190
Pentosidine, fluorescence, acid/pepsin soluble effect adjusted for
Furosine, CML	4	4.8	0.3034	0.020
Furosine effect adjusted for
DCCT mean A1C	1	22.2	<0.0001	0.092
EDIC study mean A1C	1	33.5	<0.0001	0.139
CML effect adjusted for
DCCT mean A1C	1	14.4	<0.0001	0.061
EDIC study mean A1C	1	27.6	<0.0001	0.114

Dependent variable: three or more–step progression of retinopathy on the Early Treatment of Diabetic Retinopathy Scale or scatter laser therapy from DCCT close out through EDIC study year 10. As defined in the statistical methods section, χ² and P values are from likelihood ratio test, and R² is entropy R².