TABLE 1

Plasma total homocysteine and hepatic activities of enzymes of homocysteine metabolism

5 weeks11 weeks
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Plasma total homocysteine (μmol/l)4.8 ± 0.5a3.6 ± 0.2b7.5 ± 0.4a3.1 ± 0.3b
MAT0.49 ± 0.02a0.6 ± 0.04b1.3 ± 0.09a1.7 ± 0.09b
CBS3.9 ± 0.4a7.0 ± 1.0b6.3 ± 0.9a11.2 ± 1.9b
GNMT0.52 ± 0.06a0.73 ± 0.04b0.67 ± 0.08a1.0 ± 0.09b
CGL16.5 ± 2.3a22.3 ± 2.8b16.5 ± 1.4a38.4 ± 4.2b
Methionine synthase0.033 ± 0.002a0.029 ± 0.002b0.032 ± 0.0030.035 ± 0.003
MTHFR0.09 ± 0.01a0.11 ± 0.01b0.09 ± 0.020.1 ± 0.02
BHMT0.4 ± 0.04a0.72 ± 0.06b0.34 ± 0.06a0.76 ± 0.08b
Choline dehydrogenase2.7 ± 0.53.2 ± 0.72.4 ± 0.4a3.1 ± 0.6b
  • Data are means ± SD for six rats. In each group, enzyme activities are expressed as micromoles of product synthesized per minute per 100 g body weight. Differences in superscript letters signify significant differences within each age-group (P < 0.05).