TABLE 4

Homocysteine export from isolated hepatocytes

Homocysteine export (nmol · mg dry wt−1 · 30 min)
5 weeks11 weeks
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Methionine1.17 ± 0.231.21 ± 0.251.64 ± 0.612.03 ± 0.92
Methionine + betaine0.86 ± 0.12*0.52 ± 0.08*0.89 ± 0.45*0.32 ± 0.26*
  • Data are means ± SD; n = 3 for 5 weeks and n = 5 for 11 weeks. Hcy export was measured in hepatocytes isolated from ZDF rats incubated with 0.1 mmol/l methionine ± 0.3 mmol/l betaine.

  • * Significant difference from corresponding incubations without betaine (P < 0.05).