TABLE 5

Choline and related metabolite concentrations in the liver of ZDF fa/? and ZDF fa/fa rats aged 5 and 11 weeks

Metabolite5 weeks11 weeks
ZDF fa/?ZDF fa/faZDF fa/?ZDf fa/fa
Betaine17.6 ± 3.6a9.9 ± 1.4b5.3 ± 0.7a2.5 ± 0.7b
Choline0.06 ± 0.030.04 ± 0.010.04 ± 0.010.03 ± 0.01
Glycerophosphorylcholine0.6 ± 0.04a1.0 ± 0.2b1.5 ± 0.1a0.96 ± 0.1b
Phosphorylcholine1.2 ± 0.27a2.1 ± 0.3b1.9 ± 0.3a2.9 ± 0.9b
Phosphatidylcholine28.1 ± 2.829.2 ± 1.425.3 ± 5.2a19.3 ± 2.0b
Sphingomyelin3.3 ± 0.3a2.9 ± 0.2b3.4 ± 0.4a2.8 ± 0.3b
  • Data are means ± SD (μmol/g) for six rats. Differences in superscript letters signify a significant difference from the ZDF fa/? rats of the same age (P < 0.05).