TABLE 1

General characteristics of subjects

VariablenMeans ± SD
Age (years)2,777*47.4 ± 12.5
Postmenopausal (%)2,45447.7
Obesity-related variables
    Leptin (ng/ml)2,77716.5 ± 11.9
    BMI (kg/m2)2,75824.7 ± 4.4
    Weight (kg)2,75965.3 ± 11.8
    Waist circumference (cm)2,70778.3 ± 10.2
    Total fat (kg)2,71823.4 ± 8.8
    Total fat (%)2,67735.6 ± 8.0
    Central fat (kg)2,6951.33 ± 0.73
    Central fat (%)2,69531.2 ± 11.5
Insulin sensitivity
    Fasting glucose (mmol/l)2,3194.49 ± 0.56
    Fasting insulin (pmol/l)1,9926.90 ± 5.40
    2-h glucose (mmol/l)7595.18 ± 1.10
    2-h insulin (μU/ml)75933.3 ± 23.1
    SiM (1011 · l · pmol−1 · mmol−1)75989.5 ± 68.5
Other components of the metabolic syndrome
    Triglyceride (mmol/l)2,4851.27 ± 0.80
    HDLc (mmol/l)2,6061.55 ± 0.39
    SBP§ (mmHg)2,586120.9 ± 17.6
    DBP§ (mmHg)2,58676.1 ± 11.1
  • * Number of subjects (842 monozygotic and 1,935 dizygotic) with leptin data and genotype data on at least one tSNP.

  • Nonfasting subjects, patients with either type 1 or type 2 diabetes, and patients on any antidiabetic drugs were all excluded.

  • Subjects using lipid-lowering agents were excluded.

  • § Subjects using antihypertensive medications were excluded. HDLc, HDL cholesterol.