TABLE 4

Association analyses of PTPN1 tSNPs with SiM, fasting insulin, and components of metabolic syndrome

SNPNo.Means ± SDP
11/12/22111222GEE*STDT
rs6067484SiM342/230/4789.3 ± 65.491.1 ± 67.488.7 ± 96.6NSNS
Insulin921/618/1156.70 ± 5.386.85 ± 5.337.25 ± 5.28NSNS
Glucose1076/745/1244.48 ± 0.534.50 ± 0.584.41 ± 0.52NSNS
SBP1195/808/141121.1 ± 17.9120.3 ± 17.1122.1 ± 17.7NSNS
TG1171/769/1371.26 ± 0.811.28 ± 0.791.26 ± 0.60NSNS
HDLc1222/800/1461.58 ± 0.401.52 ± 0.361.53 ± 0.38NSNS
Waist circ1255/850/15078.1 ± 10.278.5 ± 10.178.6 ± 12.4NSNS
rs1885177SiM162/302/13688.6 ± 67.094.9 ± 75.881.6 ± 70.20.0130.039
Insulin535/923/4156.66 ± 5.196.72 ± 4.897.37 ± 6.43NSNS
Glucose598/1106/4754.47 ± 0.554.51 ± 0.544.47 ± 0.57NSNS
SBP691/1198/538121.6 ± 17.4120.2 ± 17.0121.1 ± 17.4NSNS
TG655/1152/5181.30 ± 0.811.23 ± 0.751.28 ± 0.89NSNS
HDLc695/1207/5421.56 ± 0.391.54 ± 0.381.56 ± 0.39NSNS
Waist circ708/1270/56278.1 ± 10.178.4 ± 9.878.6 ± 10.9NSNS
rs2282146SiM553/100/190.7 ± 69.781.5 ± 64.319.6 ± 0.00.0490.062
Insulin1462/238/116.93 ± 5.356.81 ± 5.709.86 ± 6.72NSNS
Glucose1684/295/114.46 ± 0.554.53 ± 0.574.31 ± 0.46NSNS
SBP1870/333/14120.5 ± 17.6121.1 ± 16.9125.3 ± 20.9NSNS
TG1807/315/131.26 ± 0.771.26 ± 0.921.29 ± 0.87NSNS
HDLc1894/332/131.55 ± 0.391.53 ± 0.411.65 ± 0.28NSNS
Waist circ1966/341/1278.2 ± 10.179.2 ± 10.978.3 ± 11.0NSNS
rs718049SiM252/300/8791.6 ± 68.792.1 ± 71.878.4 ± 78.2<0.0010.002
Insulin681/806/2486.57 ± 4.746.92 ± 5.167.97 ± 7.370.0040.028
Glucose790/937/2834.47 ± 0.554.51 ± 0.554.54 ± 0.620.045NS
SBP892/1043/315121.0 ± 17.6120.8 ± 17.4122.5 ± 17.40.0170.025
TG865/986/3001.25 ± 0.811.29 ± 0.821.28 ± 0.770.023NS
HDLc899/1026/3181.57 ± 0.411.54 ± 0.381.54 ± 0.38NSNS
Waist circ933/1094/32978.0 ± 9.978.6 ± 9.979.1 ± 11.60.0220.008
rs3787348SiM173/316/12192.4 ± 83.292.1 ± 68.987.4 ± 68.1NSNS
Insulin426/824/3547.73 ± 6.976.82 ± 5.206.88 ± 5.46NSNS
Glucose500/961/3984.52 ± 0.574.49 ± 0.554.49 ± 0.56NSNS
SBP582/1078/464121.2 ± 18.3121.0 ± 17.9122.3 ± 17.9NSNS
TG554/1045/4421.30 ± 0.751.26 ± 0.791.31 ± 0.83NSNS
HDLc578/1101/4621.53 ± 0.341.55 ± 0.391.54 ± 0.38NSNS
Waist circ605/1140/47878.8 ± 11.278.1 ± 9.977.7 ± 10.0NSNS
1484insGSiM554/58/388.4 ± 67.584.3 ± 71.699.4 ± 55.2NSNS
Insulin1462/148/76.94 ± 5.576.67 ± 4.855.39 ± 2.63NSNS
Glucose1693/184/74.78 ± 0.564.57 ± 0.574.44 ± 0.36NSNS
SBP1893/201/6120.7 ± 17.2120.0 ± 16.9140.4 ± 42.0NSNS
TG1800/204/71.28 ± 0.781.15 ± 0.580.96 ± 0.300.029NS
HDLc1882/208/71.54 ± 0.381.59 ± 0.401.78 ± 0.47NSNS
Waist circ1971/212/978.3 ± 10.378.2 ± 10.079.7 ± 8.0NSNS
  • * Age-adjusted P value;

  • P value under the recessive genetic model;

  • P value under the dominant genetic model. HDLc, HDL cholesterol; TG, triglyceride; Waist circ, waist circumference.