TABLE 2

Baseline measurements of vascular reactivity and biochemical markers of endothelial function

AllType 1 diabetesType 2 diabetesP
Resting brachial artery diameter (mm)3.62 ± 0.753.23 ± 0.583.85 ± 0.75<0.0001
FMD6.1 ± 3.36.3 ± 3.36.0 ± 3.2NS
NID12.6 ± 7.112.6 ± 6.812.6 ± 7.3NS
Baseline blood flow before the iontophoresis of acetylcholine (volts)0.94 ± 0.220.92 ± 160.95 ± 0.25NS
Ach-induced skin vasodilation58 ± 2759 ± 2957 ± 25NS
Sodium nitroprusside−induced skin vasodilation36 ± 1840 ± 1733 ± 170.03
Intracellular adhesion molecule (ng/ml)260 ± 53262 ± 35259 ± 62NS
Vascular cellular adhesion molecule (ng/ml)729 ± 141726 ± 117730 ± 156NS
Endothelin-1 (pg/ml)0.91 ± 0.410.75 ± 0.221.01 ± 0.460.01
TNF-α (pg/ml)3.36 ± 2.322.57 ± 1.603.82 ± 2.560.04
High-sensitivity CRP (mg/l)3.9 ± 5.52.98 ± 3.634.52 ± 6.38NS
von Willebrand factor (%)128 ± 41127 ± 45129 ± 40NS
PAI-1 antigen (ng/ml)26 ± 2216 ± 1431 ± 240.01
tPA antigen (ng/ml)6.1 ± 2.94.4 ± 1.67.1 ± 3.0<0.0001
  • Data are means ± SD. Data for FMD, NID, Ach-induced skin vasodilation, and sodium nitroprusside–induced skin vasodilation represent percent of increase over baseline. P values indicate differences between type 1 and type 2 diabetes.