TABLE 4

Changes in endothelial function between baseline and middle (6-month) visit

All
Type 1 diabetes
Type 2 diabetes
Vitamin EPlaceboVitamin EPlaceboVitamin EPlacebo
n34329122520
Brachial artery diameter (mm)
    Baseline3.78 ± 0.783.43 ± 0.593.32 ± 0.713.16 ± 0.553.93 ± 0.763.60 ± 0.57
    6 months3.89 ± 0.863.53 ± 0.773.29 ± 0.683.31 ± 0.864.09 ± 0.823.67 ± 0.69
    PNSNSNSNSNSNS
FMD
    Baseline5.7 ± 2.55.7 ± 2.85.7 ± 1.86.6 ± 2.15.6 ± 2.85.2 ± 3.0
    6 months6.4 ± 3.45.9 ± 2.96.8 ± 1.55.8 ± 3.66.3 ± 3.85.9 ± 2.4
    PNSNSNSNSNSNS
NID
    Baseline13.2 ± 4.215.5 ± 5.715.2 ± 4.716.4 ± 6.212.4 ± 3.914.9 ± 5.4
    6 months12.8 ± 4.915.7 ± 6.515.8 ± 5.117.6 ± 9.111.6 ± 4.414.6 ± 4.0
    PNSNSNSNSNSNS
Ach
    Baseline58 ± 2762 ± 2674 ± 3557 ± 2553 ± 2265 ± 27
    6 months55 ± 3076 ± 3557 ± 3678 ± 3554 ± 2875 ± 36
    PNS0.01NS0.03NSNS
Sodium nitroprusside
    Baseline32 ± 1738 ± 1941 ± 1840 ± 2129 ± 1537 ± 18
    6 months37 ± 1746 ± 2742 ± 1952 ± 2836 ± 1743 ± 27
    PNSNSNSNSNSNS
Endothelin (pg/ml)
    Baseline0.90 ± 0.470.94 ± 0.370.66 ± 0.230.79 ± 0.231.01 ± 0.551.03 ± 0.42
    6 months0.98 ± 0.650.84 ± 0.400.60 ± 0.150.63 ± 0.251.13 ± 0.710.98 ± 0.43
    PNS0.02NS0.002NSNS
HbA1c (%)
    Baseline7.2 ± 1.37.5 ± 1.27.6 ± 1.37.9 ± 1.17.1 ± 1.37.2 ± 1.2
    6 months7.4 ± 1.57.2 ± 1.17.8 ± 1.57.8 ± 0.97.2 ± 1.57.0 ± 1.2
    PNS0.05NSNSNSNS
Total cholesterol (mg/dl)
    Baseline182 ± 35194 ± 31173 ± 25205 ± 16185 ± 36188 ± 37
    6 months186 ± 36186 ± 31182 ± 36184 ± 25188 ± 37187 ± 35
    PNSNSNS0.01NSNS
HDL cholesterol (mg/dl)
    Baseline56 ± 1464 ± 1868 ± 1476 ± 2152 ± 1256 ± 12
    6 months55 ± 1360 ± 1567 ± 1167 ± 1650 ± 1156 ± 13
    PNS0.06NS0.02NSNS
  • Data are means ± SD. Data for FMD, NID, and Ach represent percent of increase over baseline. P indicates differences between baseline and mid-visit values.