TABLE 1

Expression of selected genes in sox4+/+ vs. sox4−/− pancreases at e12.5

Gene nameUnigeneFold difference*
Ring finger protein 122Mm0.295322.26 ± 0.27
Insulin 1Mm0.462691.84 ± 0.05
Cell division cycle 6 homolog (Cdc6)Mm0.209121.74 ± 0.10
Peroxiredoxin 2Mm0.701301.61 ± 0.10
Cyclin-dependent kinase 4 (Cdk4)Mm0.68391.44 ± 0.08
Insulin 2Mm0.49461.42 ± 0.09
Glutathione peroxidase 1Mm0.10901.42 ± 0.09
Nkx6.1Mm0.1930721.38 ± 0.08
NeuroD1Mm0.46360.79 ± 0.07
Transforming growth factor-β receptor 1Mm0.1975520.69 ± 0.03
Cyclin D1Mm0.2730490.68 ± 0.03
GastrinMm0.47670.65 ± 0.02
Sox11Mm0.417020.63 ± 0.08
Neurogenin3Mm0.572360.61 ± 0.02
Growth hormoneMm0.3439340.58 ± 0.03
DEAD box polypeptide 3, Y-linkedMm0.3029380.51 ± 0.04
DEAD box polypeptide 4Mm0.128180.50 ± 0.02
Metallothionein 1 (Mt1)Mm0.1929910.50 ± 0.05
BCL2 interacting protein 1 (Bnip3)Mm0.21590.49 ± 0.03
Metallothionein 2 (Mt2)Mm0.1472260.43 ± 0.02
Apoptotic chromatin condensation inducer 1Mm0.2970780.26 ± 0.02
Alpha fetoproteinMm0.3585700.25 ± 0.02
  • Data are the means of six ratios ± SEM.

  • *

    * Fold difference was calculated by taking the ratio of the signal from sox4+/+ RNA relative to sox4−/− RNA.

  • This gene was spotted twice on the array, and the fold difference shown is the mean of both spots.