TABLE 2

Sorbitol pathway intermediate concentrations* in sciatic nerve and retina of control and diabetic rats with and without fidarestat treatment

GlucoseSorbitolFructose
Sciatic nerve
    Control3.39 ± 0.100.123 ± 0.0101.20 ± 0.11
    Control plus fidarestat3.34 ± 0.120.129 ± 0.0091.31 ± 0.07
    Diabetic13.9 ± 0.591.30 ± 0.105.57 ± 0.20
    Diabetic plus fidarestat13.2 ± 0.540.077 ± 0.007##1.30 ± 0.09##
Retina
    Control9.3 ± 0.731.75 ± 0.131.34 ± 0.25
    Control plus fidarestat10.2 ± 0.771.57 ± 0.141.28 ± 0.31
    Diabetic95 ± 7.411.4 ± 0.815.34 ± 0.52
    Diabetic plus fidarestat106 ± 8.71.81 ± 0.34##1.72 ± 0.43##
  • Data are means ± SE (n = 8–10).

  • *

    * Expressed in mmol/g wet wt for sciatic nerve and mmol/g protein for retina.

  • Significantly different from controls (P < 0.01).

  • Significantly different from untreated diabetic rats (P < 0.01).