Univariate and multivariate logistic regression analyses of factors associated with incident CVD events among type 2 diabetic patients
Variables | Univariate | Multivariate model 1 | Multivariate model 2 | Multivariate model 3 |
---|---|---|---|---|
NAFLD | ||||
OR | 1.91 | 1.9 | 1.84 | 1.53 |
95% CI | 1.4–2.2 | 1.4–2.2 | 1.4–2.1 | 1.1–1.7 |
P values | 0.001 | 0.001 | 0.001 | 0.02 |
ATP III–defined metabolic syndrome | ||||
OR | 1.64 | 1.64 | 1.62 | 1.58 |
95% CI | 1.3–2.5 | 1.3–2.3 | 1.3–2.1 | 1.3–2 |
P values | 0.001 | 0.001 | 0.001 | 0.01 |
Age | ||||
OR | 1.14 | 1.13 | 1.13 | 1.12 |
95% CI | 1.07–1.16 | 1.07–1.14 | 1.07–1.14 | 1.06–1.14 |
P values | 0.001 | 0.001 | 0.001 | 0.001 |
Sex | ||||
OR | 1.50 | 1.48 | 1.46 | 1.46 |
95% CI | 1.2–2 | 1.2–2 | 1.2–1.9 | 1.2–1.9 |
P values | 0.001 | 0.001 | 0.001 | 0.001 |
Diabetes duration | ||||
OR | 1.08 | NS | NS | NS |
95% CI | 0.8–1.3 | NS | NS | NS |
P values | NS | NS | NS | NS |
A1C | ||||
OR | 1.51 | 1.46 | NS | NS |
95% CI | 1.1–4.9 | 1.02–4.2 | NS | NS |
P values | 0.02 | 0.05 | NS | NS |
Smoking status | ||||
OR | 1.44 | 1.42 | 1.40 | 1.40 |
95% CI | 1.1–2.0 | 1.1–2.0 | 1.1–1.9 | 1.1–1.9 |
P values | 0.01 | 0.01 | 0.01 | 0.01 |
LDL cholesterol | ||||
OR | 1.18 | NS | NS | NS |
95% CI | 0.9–1.4 | NS | NS | NS |
P values | NS | NS | NS | NS |
GGT | ||||
OR | 1.42 | 1.40 | 1.27 | NS |
95% CI | 1.1–2.0 | 1.1–1.9 | 1.05–1.7 | NS |
P values | 0.001 | 0.001 | 0.01 | NS |
Use of medications | ||||
OR | 1.0 | NS | NS | NS |
95% CI | 0.7–1.2 | NS | NS | NS |
P values | NS | NS | NS | NS |
Model 1: adjustment for age and sex; model 2: further adjustment for smoking history, diabetes duration, A1C, LDL cholesterol, GGT levels, and use of medications (i.e., hypoglycemic, antihypertensive, lipid-lowering, or antiplatelet drugs); model 3: additional adjustment for the presence of metabolic syndrome or NAFLD (for the first and second variables in the table) or additional adjustment for the presence of metabolic syndrome and NAFLD (for all other variables in the table).