Body iron stores by HFE variants H63D, C282Y, and the compound heterozygotes*
| H63D | P | C282Y | P | The compound heterozygotes | P | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HH | HD | DD | DD vs. HH | DD vs. HD | CC | CY + YY | HHCC | HDCY | ||||||||
| Ferritin (ng/ml) | ||||||||||||||||
| Control | 782 (44.7) | 302 (48.4) | 24 (82.3) | 0.03 | 0.06 | 982 (45.2) | 137 (58.0) | 0.03 | 669 (43.4) | 23 (73.7) | 0.03 | |||||
| Diabetic | 498 (69.4) | 184 (68.0) | 23 (86.5) | 0.32 | 0.28 | 616 (67.4) | 94 (87.4) | 0.03 | 423 (67.4) | 21 (121.5) | 0.01 | |||||
| Total | 1,280 (55.1) | 486 (57.4) | 47 (85.6) | 0.01 | 0.02 | 1,598 (54.6) | 231 (72.2) | 0.0006 | 1,092 (53.5) | 44 (99.5) | 0.0002 | |||||
| Ratio of transferrin receptor to ferritin | ||||||||||||||||
| Control | 782 (66.7) | 302 (60.9) | 24 (32.1) | 0.02 | 0.03 | 982 (66.7) | 137 (47.9) | 0.006 | 669 (70.1) | 23 (38.5) | 0.02 | |||||
| Diabetic | 498 (46.5) | 184 (45.2) | 23 (30.9) | 0.07 | 0.11 | 616 (47.5) | 94 (34.5) | 0.01 | 423 (48.9) | 21 (22.4) | 0.002 | |||||
| Total | 1,280 (56.3) | 486 (52.5) | 47 (31.2) | 0.001 | 0.005 | 1,598 (56.8) | 231 (40.0) | <0.0001 | 1,092 (59.1) | 44 (27.7) | <0.0001 | |||||
Data are n (means).
* Adjusting for age, BMI, alcohol consumption, smoking, physical activity, aspirin use, family history of diabetes, and postmenopausal hormone use.