TABLE 2

Body iron stores by HFE variants H63D, C282Y, and the compound heterozygotes*

H63D
P
C282Y
PThe compound heterozygotes
P
HHHDDDDD vs. HHDD vs. HDCCCY + YYHHCCHDCY
Ferritin (ng/ml)
    Control782 (44.7)302 (48.4)24 (82.3)0.030.06982 (45.2)137 (58.0)0.03669 (43.4)23 (73.7)0.03
    Diabetic498 (69.4)184 (68.0)23 (86.5)0.320.28616 (67.4)94 (87.4)0.03423 (67.4)21 (121.5)0.01
    Total1,280 (55.1)486 (57.4)47 (85.6)0.010.021,598 (54.6)231 (72.2)0.00061,092 (53.5)44 (99.5)0.0002
Ratio of transferrin receptor to ferritin
    Control782 (66.7)302 (60.9)24 (32.1)0.020.03982 (66.7)137 (47.9)0.006669 (70.1)23 (38.5)0.02
    Diabetic498 (46.5)184 (45.2)23 (30.9)0.070.11616 (47.5)94 (34.5)0.01423 (48.9)21 (22.4)0.002
    Total1,280 (56.3)486 (52.5)47 (31.2)0.0010.0051,598 (56.8)231 (40.0)<0.00011,092 (59.1)44 (27.7)<0.0001
  • Data are n (means).

  • *

    * Adjusting for age, BMI, alcohol consumption, smoking, physical activity, aspirin use, family history of diabetes, and postmenopausal hormone use.