TABLE 3

Associations of HFE variants H63D, C282Y, and the compound heterozygotes with the risk of type 2 diabetes among U.S. women

VariantsControl subjectsCase subjectsOR
Age and BMI adjustedMultivariate adjusted*
H63D
    HH782 (70.6)489 (70.6)1.01.0
    HD302 (27.3)184 (26.1)0.97 (0.78–1.22)0.95 (0.75–1.20)
    DD24 (2.1)23 (3.3)1.68 (0.91–3.12)1.84 (0.96–3.53)
C282Y
    CC982 (87.8)616 (86.8)1.01.0
    CY + YY137 (12.2)94 (13.2)1.13 (0.84–1.52)1.16 (0.85–1.59)
Compound heterozygotes
    HHCC669 (96.7)423 (95.3)1.01.0
    HDCY23 (3.3)21 (4.7)1.61 (0.86–3.02)1.57 (0.80–3.09)
  • Data are n (%) or OR (95% CI).

  • *

    * Adjusting for age, BMI, alcohol consumption, smoking, physical activity, family history of diabetes, race, and postmenopausal hormone use.