TABLE 1

Phenotypic characteristics of genotyped men and women of the TOPS families and the MONICA Augsburg LVH substudy population

MenWomen
TOPS
    n307788
     Age (years)50.9 ± 17.646.0 ± 14.4
    Obesity affection status (%)24.750.1
    BMI (kg/m2)
        Total sample29.1 ± 5.633.1 ± 8.4
        Affected37.0 ± 4.5 (75)39.8 ± 6.2 (393)
        Unaffected24.5 ± 2.4 (141)24.3 ± 2.4 (244)
    Body weight (kg)93.2 ± 21.189.7 ± 24.2
    Waist-to-hip ratio0.95 ± 0.090.85 ± 0.10
    Hypertension (%)41.836.0
    Type 2 diabetes (%)7.97.8
    Current smoker (%)37.231.0
MONICA
    n724694
    Age (years)52.5 ± 13.951.6 ± 13.6
    Obesity affection status (%)9.916.1
    BMI (kg/m2)
        Total sample27.0 ± 3.526.4 ± 4.7
        Affected34.6 ± 2.5 (50)35.0 ± 2.7 (89)
        Unaffected24.9 ± 2.1 (457)23.8 ± 2.5 (463)
    Body weight (kg)81.9 ± 11.568.8 ± 11.9
    Waist-to-hip ratio0.92 ± 0.060.80 ± 0.06
    Hypertension (%)41.933.4
    Type 2 diabetes (%)5.23.0
    Current smoker (%)30.223.6
  • Data are means ± SD, with (n) where appropriate, unless otherwise indicated. The obesity affection status is defined as a BMI >32 kg/m2. Hypertension is defined as systolic blood pressure >140 mmHg, diastolic blood pressure >90 mmHg, or a history of hypertension. Because of nonindependent observations in TOPS families, characteristics are descriptive. Subjects classified as “unknown” are not shown.