TABLE 2

TDT of association with obesity-affection status in 148 trios selected from the TOPS families and family-based association test using FBAT analysis

SNP/haplotypeFrequencyAlleleTrio TDT (n probands with allele)
FBAT P
TransmittedNot transmittedP
rs5090350.71G24370.096 (0.137)0.021 (0.030)
0.29A3724
rs5721690.71G23380.055 (0.079)0.032 (0.046)
0.29A3823
rs5193840.73T23370.070 (0.100)0.010 (0.014)
0.27A3723
rs5126920.74A21380.027 (0.039)0.033 (0.047)
0.26T3821
rs8634410.73G22370.051 (0.073)0.012 (0.017)
0.27C3722
Haplotype 10.69G-G-T-A-G0.025 (NA)
Haplotype 20.25A-A-A-T-C0.045 (NA)
Haplotype 30.03A-A-T-A-G0.905 (NA)
  • SNPs are shown as rs numbers from the dbSNP database. Haplotypes are derived from the five SNPs contributing to the high-LD block (r2 >0.75). P values were corrected for multiple testing (shown in parentheses). P values for trio TDT are based on the TDT statistic; P values for FBAT are based on the FBAT (−e option) statistic. NA, correction not applied.