TABLE 3

Haplotype structures of the LD block with their frequencies and association with obesity in the general population (MONICA Augsburg LVH substudy)

Haplotypes
Frequency
Asymptotic PEmpirical P
IDrs509035rs572169rs519384rs512692rs863441ObeseNon-obese
1GGTAG0.610.690.0020.002
2AAATC0.330.250.0020.001
3AATAG0.040.040.4740.452
  • Haplotypes are derived from the five SNPs contributing to the high-LD block (r2 > 0.75). Asymptotic P values are based on haplotype trend regression analysis; empirical P values are based on 50,000 permutations. The permutation test was implemented in the haplotype trend regression analysis program.