TABLE 4

Summary of the association of SNPs in the total MONICA Augsburg LVH substudy sample as well as in matched case and control subjects

SNPCase subjects
Control subjects
Allele 2 vs. 1
Genotype 22 vs. 11
Genotypes 22 + 12 vs. 11
111222MAF111222MAFOR (95% CI)PP(corr)OR (95% CI)PP(corr)OR (95% CI)PP(corr)
rs509035
    Matched4759170.38173166210.291.50 (1.10–2.03)0.0090.0132.98 (1.46–6.10)0.0020.0031.50 (0.99–2.27)0.0580.085
    Total study4965170.38424375690.301.45 (1.11–1.90)0.0070.0102.13 (1.16–3.91)0.0130.0191.60 (1.10–2.33)0.0150.022
rs572169
    Matched5062170.37182157250.281.49 (1.11–2.01)0.0090.0132.48 (1.24–4.94)0.0090.0131.58 (1.05–2.38)0.0280.041
    Total study5267170.37451371800.291.42 (1.09–1.85)0.0100.0151.84 (1.02–3.35)0.0420.0621.62 (1.12–2.34)0.0110.016
rs519384
    Matched5660150.34207155160.251.59 (1.18–2.16)0.0030.0043.47 (1.62–7.44)0.00090.0011.62 (1.09–2.42)0.0180.026
    Total study5965150.34501361580.261.48 (1.13–1.94)0.0040.0062.20 (1.17–4.12)0.0120.0181.62 (1.13–2.33)0.0080.012
rs512692
    Matched5755150.33200154150.251.51 (1.11–2.06)0.0080.0123.51 (1.62–7.61)0.00090.0011.45 (0.97–2.18)0.0700.103
    Total study6060150.33482356560.261.41 (1.07–1.86)0.0140.0212.15 (1.15–4.04)0.0150.0221.46 (1.02–2.11)0.0400.059
rs863441
    Matched5656180.35204149130.241.74 (1.28–2.37)0.00030.00045.04 (2.33–10.9)0.000010.000021.66 (1.11–2.49)0.0130.019
    Total study5961180.35493355550.261.56 (1.20–2.04)0.0010.0022.74 (1.51–5.00)0.00070.0011.61 (1.12–2.31)0.0090.013
  • SNPs shown as rs numbers from the dbSNP database. Odds ratios (ORs) with 95% CIs are based on the Armitage test for trend. MAF, minor allele frequency; P(corr), P value corrected for multiple testing.