TABLE 1

Multipoint linkage analysis peaks with LOD >1.5 (corresponding to P < 0.005)

Chromosome locationDistance (cM)Closest marker(s)LOD (P)Nearby linkages in related traits in Old Order AmishNearby linkages to related traits in other populations
3q27209D3S1602/D3S15802.13 (0.0009)Multiple metabolic syndrome QTLs (BMI, waist, hip, weight, insulin, insulin:glucose): LOD = 2.4–3.5 @ 189–203 cM (10) Diabetes: MLS = 4.67 and MLB- LOD = 3.43 @ D3S1580 (11)
7q11–2194D7S6691.87 (0.0017)Disinhibition (eating behavior): LOD = 1.65 @ 109 cM (31) Glucose 60: LOD = 1.45 @ 100 cM (32)
9q34144D9S2901.54 (0.0039)Total serum cholesterol: LOD = 1.61 @ 131 cM (33)
10p12-p1444D10S5481.73 (0.0024)BMI-adjusted leptin: LOD = 2.73 @ 71 cM (26)Adiponectin levels: LOD = 1.9 @ 67 cM (27) Obesity: MLS = 4.85 @ 55 cM (28) BMI: LODFA = 1.7 @ 20 cM (29)
16p1315D16S4071.69 (0.0026)BMI: LOD = 1.66 @ 1 cM (26) Leptin: LOD = 1.72 @ 16 cM (26) Fasting glucose to fasting insulin: LOD = 1.54 @ 26 cM (34)
  • LODFA, paternal LOD; MLB, maximum likelihood binomial; MLS, maximum likelihood score.