TABLE 2

Association of six APM1 SNPs with adiponectin levels

SNP nameGene regionPosition (from ATG start codon)Base changeMinor allele frequencyMean adiponectin level (μg/ml)
P (additive model)
111222
rs266729promoter−11,374C→G0.4711.8 ± 1.0 (170)12.1 ± 0.5 (279)11.7 ± 0.7 (104)0.6471
rs182052promoter−10,066A→G0.4512.0 ± 1.0 (165)12.1 ± 0.5 (270)11.8 ± 0.7 (116)0.9507
rs822396intron 1−3,971A→G0.2411.9 ± 1.0 (348)11.4 ± 0.5 (190)11.3 ± 0.9 (34)0.1917
rs2241766exon 2+45T→G (Gly15Gly)0.0811.7 ± 1.0 (463)13.2 ± 0.6 (81)15.0 ± 2.6 (4)0.0010
rs1501299intron 2+276G→T0.2011.3 ± 1.0 (345)12.1 ± 0.5 (180)14.3 ± 1.2 (19)0.0140
SNP +20193′ UTR+2,019insA→delA0.3010.8 ± 1.0 (283)12.1 ± 0.5 (252)13.8 ± 0.8 (50)<0.0001
  • Data are means ± SE (n of individuals). Mean adiponectin levels are adjusted for age and age squared; all analyses are adjusted for sex and sex-specific age and age squared. ins, insertion; del, deletion; 11, homozygous for major allele; 12, heterozygous; 22, homozygous for minor allele.