TABLE 1

Potential cellular targets of insulin-induced ROS susceptible to biochemical regulation by oxidative inhibition

AcronymEnzyme
PTP1BProtein-tyrosine phosphatase 1B
PTPsOther PTPs potentially involved in insulin action (e.g., LAR)
PTENPhosphatase and tensin homolog deleted on chromosome 10
PP2AProtein serine/threonine phosphatase 2A
MKP-1MAP kinase phosphatase-1; dual-specificity (serine/tyrosine) phosphatase
Dual-specificity PTPsOther dual-specificity regulatory PTPs
  • See text for discussion.