TABLE 2

Estimated risk ratios (RRs) and 95% CIs for type 1 diabetes in siblings of childhood-onset type 1 diabetic patients fitting explanatory variables

Univariate analysis
Adjusted for other variables
VariableRR95% CIPRR95% CIP
Sex
    Female1.001.00
    Male1.261.08–1.470.0041.291.10–1.500.002
Diagnosis age of index case (years)
    ≥151.001.00
    10–141.351.03–1.770.031.431.09–1.880.009
    5–92.271.73–2.96<0.00012.501.90–3.27<0.0001
    0–44.053.06–5.36<0.00014.603.46–6.10<0.0001
    Test for trend<0.0001<0.0001
Young-onset diabetes in fathers
    No1.001.00
    Yes2.111.33–2.320.0011.951.23–3.100.004
Maternal age at delivery (years)
    <251.001.00
    25–291.401.13–1.720.0021.311.03–1.660.03
    30–341.581.27–1.98<0.00011.331.00–1.760.05
    ≥352.231.77–2.80<0.00011.851.35–2.550.0002
    Test for trend<0.00010.02
Paternal age at delivery (years)
    <251.001.00
    25–291.000.77–1.310.980.960.72–1.270.78
    30–341.501.16–1.940.0021.381.02–1.870.04
    ≥351.811.41–2.33<0.00011.501.07–2.110.02
    Test for trend<0.00010.002