TABLE 2

Fasting plasma metabolite concentrations in control subjects and patients with type 2 diabetes before and after weight loss

ControlP value, control vs. before weight lossBefore weight lossAfter weight lossP value, before vs. after weight loss
n1088
Glucose (mmol/l)4.9 ± 0.2<0.00018.8 ± 0.56.4 ± 0.30.00037
Insulin (pmol/l)60 ± 6NS174 ± 4866 ± 60.03
C-peptide (pmol/l)NDND1.14 ± 0.360.73 ± 0.06NS
Glucagon (pg/ml)57 ± 6NS77 ± 758 ± 60.02
Cortisol (μg/dl)19 ± 3NS16 ± 112 ± 2NS
Total cholesterol (mg/dl)168 ± 8NS202 ± 18177 ± 17<0.05
HDL (mg/dl)57 ± 3NS40 ± 236 ± 3NS
LDL (mg/dl)91 ± 5NS119 ± 17102 ± 10NS
Triglycerides (mg/dl)104 ± 160.01212 ± 38187 ± 58NS
Free fatty acids (mmol/l)0.49 ± 0.07NS0.49 ± 0.050.49 ± 0.05NS
Leptin (pg/ml)4.9 ± 1.0NS11.9 ± 2.57.5 ± 1.90.01
Resistin (ng/ml)25.5 ± 1.4NS24.5 ± 2.521.8 ± 1.7NS
IL-6 (pg/ml)NDND0.49 ± 0.160.81 ± 0.29NS
Adiponectin (μg/ml)14.3 ± 2.00.001465.8 ± 1.15.1 ± 0.6NS
TNF-α (pg/ml)NDND1.524 ± 0.0711.347 ± 0.0470.03
  • Data are means ± SE.