Multivariate association of diabetic retinopathy with renal anatomic characteristics controlling for age, duration of diabetes, sex, HbA1c, mean arterial blood pressure, and BMI

Renal characteristicDiabetic retinopathy severity*
Early NPDRModerate to severe NPDR and PDRP
GBM width (nm)48.064.8<0.0002
Mesangial fractional volume0.00480.02570.03
Mesangial matrix fraction volume0.00670.01700.04
Mesangial cell fraction volume−0.00290.00630.06
Peripheral GBM surface density−0.0043−0.00950.15
Glomerulopathy index5.58.20.0001
  • *

    * Values represent the change in renal characteristic at the diabetic retinopathy severity level compared to no retinopathy (n = 89). NPDR, nonproliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.