TABLE 4

Percentage of abnormal renal anatomic characteristics by diabetic retinopathy severity

Renal characteristicDiabetic retinopathy severity
P
No DREarly NPDRModerate to severe NPDR and PDR
n8913627
Increased GBM width35 (39.3)90 (66.2)21 (77.8)<0.0001
Increased mesangial fractional volume/glomerulus11 (12.4)29 (21.3)13 (48.2)0.0002
Increased mesangial matrix fraction volume/glomerulus32 (36.0)75 (55.2)20 (74.1)0.0001
Increased Vv(MC/glom)6 (6.7)5 (3.7)4 (14.8)0.48
Decreased peripheral GBM surface density/glomerulus10 (11.2)21 (15.4)9 (33.3)0.02
Increased glomerulopathy index40 (44.9)100 (73.5)23 (85.2)<0.0001
  • Data are n (%). DR, diabetic retinopathy; NPDR, nonproliferative DR; PDR, proliferative diabetic retinopathy.