TABLE 5

Multivariate association of diabetic retinopathy with renal structural abnormalities controlling for age, duration of diabetes, sex, HbA1c, mean arterial blood pressure, and BMI

Renal characteristicDiabetic retinopathy severity
P
Early NPDRModerate to severe NPDR and PDR
n13627
Increased GBM width2.68 (1.36–5.29)3.94 (1.14–13.62)0.01
Increased mesangial fractional volume/glomerulus1.12 (0.48–2.63)2.31 (0.72–7.48)0.27
Increased mesangial matrix fraction volume/glomerulus1.41 (0.73–2.75)1.74 (0.55–5.58)0.52
Increased Vv(MC/glom)0.21 (0.05–0.89)0.57 (0.10–3.45)0.06
Decreased peripheral GBM surface density/glomerulus0.96 (0.38–2.44)1.90 (0.51–7.06)0.42
Increased glomerulopathy index2.51 (1.27–4.95)3.66 (0.96–14.02)0.02
  • Data are odds ratio (95% CI). The no retinopathy group (n = 89) is the reference group for the odds ratios. NPDR, nonproliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.