TABLE 2

Insulin secretion results (μU · islet−1 · 45 min−1) from control and type 2 diabetic islets in response to 3.3 mmol/l glucose, 16.7 mmol/l glucose, 3.3 mmol/l glucose plus 20 mmol/l arginine, or 3.3 mmol/l glucose plus 100 μmol/l glibenclamide

3.3 mmol/l glucose16.7 mmol/l glucose3.3 mmol/l glucose plus 20 mmol/l arginine3.3 mmol/l glucose plus 100 μmol/l glibenclamide
Control islets2.47 ± 0.45 (13)5.40 ± 0.90 (13)*5.53 ± 0.62 (11)*5.63 ± 0.69 (11)*
Type 2 diabetic islets2.10 ± 0.61 (13)2.50 ± 0.60 (13)3.45 ± 0.72 (10)3.71 ± 0.75 (10)
  • Numbers of pancreata studied are given in parentheses.

  • *

    * P < 0.01 vs. controls at 3.3 mmol/l glucose;

  • P < 0.05 vs. type 2 diabetic islets at 3.3 and 16.7 mmol/l glucose;

  • P < 0.05 vs. the respective values of controls.