TABLE 2

Heart rates and systolic and diastolic blood pressures during hyperinsulinemic, euglycemic (0–120 min) and then hypoglycemic (120–240 min) clamps before and after administration of diazoxide or placebo and later arginine hydrochloride

Time (min)Heart rate (bpm)
Systolic blood pressure (mmHg)
Diastolic blood pressure (mmHg)
PlaceboDiazoxidePlaceboDiazoxidePlaceboDiazoxide
−1564 ± 367 ± 3116 ± 2113 ± 363 ± 265 ± 2
067 ± 368 ± 3115 ± 3115 ± 362 ± 363 ± 2
1564 ± 270 ± 3117 ± 3118 ± 364 ± 264 ± 2
3067 ± 374 ± 3117 ± 3119 ± 363 ± 362 ± 2
4567 ± 374 ± 4116 ± 3116 ± 362 ± 261 ± 2
6068 ± 371 ± 3119 ± 2118 ± 363 ± 262 ± 3
7569 ± 379 ± 3116 ± 3115 ± 360 ± 260 ± 2
9074 ± 476 ± 4121 ± 3118 ± 363 ± 259 ± 2
10570 ± 378 ± 3116 ± 3117 ± 460 ± 256 ± 2
12073 ± 381 ± 3119 ± 3115 ± 361 ± 257 ± 2
13571 ± 380 ± 4117 ± 3115 ± 459 ± 255 ± 2
15073 ± 381 ± 4117 ± 3117 ± 359 ± 355 ± 2
16580 ± 483 ± 4116 ± 3112 ± 458 ± 352 ± 2
18077 ± 484 ± 5119 ± 4113 ± 555 ± 349 ± 3
19574 ± 481 ± 4116 ± 4112 ± 454 ± 347 ± 2
21076 ± 381 ± 4117 ± 4115 ± 455 ± 348 ± 2
22572 ± 583 ± 4116 ± 4110 ± 454 ± 246 ± 2
24072 ± 478 ± 4115 ± 3114 ± 453 ± 247 ± 2
24370 ± 479 ± 4113 ± 4107 ± 452 ± 244 ± 2
24570 ± 479 ± 4112 ± 4109 ± 452 ± 245 ± 2
24774 ± 481 ± 4114 ± 3110 ± 354 ± 347 ± 2
  • Data are means ± SE. Diazoxide (6.0 mg/kg) or placebo was given orally after the 0-min sample and arginine hydrochloride (5.0 g) was injected intravenously after the 240-min sample.