TABLE 3

Blood lactate and serum nonesterified fatty acid concentrations during hyperinsulinemic, euglycemic (0–120 min) and then hypoglycemic (120–240 min) clamps before and after administration of diazoxide or placebo and later arginine hydrochloride

Time (min)Lactate (μmol/l)
Nonesterified fatty acid (μmol/l)
PlaceboDiazoxidePlaceboDiazoxide
−15762 ± 93772 ± 95518 ± 44505 ± 49
0674 ± 54822 ± 84485 ± 33518 ± 54
15686 ± 58760 ± 75386 ± 24334 ± 35
30985 ± 78909 ± 89203 ± 31232 ± 36
451,118 ± 581,174 ± 96146 ± 24203 ± 33
601,202 ± 791,283 ± 99124 ± 22156 ± 31
751,061 ± 751,262 ± 127131 ± 26138 ± 23
901,151 ± 661,224 ± 8296 ± 13127 ± 16
1051,154 ± 801,158 ± 74107 ± 14106 ± 20
1201,089 ± 691,285 ± 81115 ± 20114 ± 20
1351,037 ± 1071,185 ± 79100 ± 13125 ± 19
1501,084 ± 1071,223 ± 107109 ± 27122 ± 28
1651,134 ± 821,174 ± 75116 ± 19148 ± 26
1801,462 ± 1151,458 ± 104121 ± 20168 ± 26
1951,601 ± 1161,509 ± 133131 ± 20118 ± 19
2101,638 ± 1341,523 ± 136124 ± 19155 ± 31
2251,559 ± 1861,460 ± 136102 ± 18134 ± 21
2401,664 ± 1611,628 ± 109128 ± 17146 ± 28
2431,661 ± 1411,619 ± 12895 ± 13166 ± 36
2451,571 ± 1181,707 ± 15392 ± 11156 ± 30
2471,892 ± 2051,618 ± 94114 ± 18143 ± 28
  • Data are means ± SE. Diazoxide (6.0 mg/kg) or placebo was given orally after the 0-min sample and arginine hydrochloride (5.0 g) was injected intravenously after the 240-min sample. P = 0.0154 for placebo vs. diazoxide for lactate measurements.