TABLE 2

Spontaneous activity at various life stages

GenotypeBody weight (g)Distance (cm)Speed composition
Rearing ∇ (n)Rearing ∇ duration (s)
% RT% MS% MFΔ
8 weeks
    ARX/Y23 ± 0.6998,816.3 ± 10,951.060.423.915.75,026.0 ± 1067.61.12 ± 0.23
    ARL−/Y21 ± 1.3466,394.8 ± 14,616.7*72.817.89.482,410.5 ± 569.5*1.20 ± 0.31
20 weeks
    ARX/Y31.90 ± 4.9699,770.8 ± 27,281.665.820.913.37,003.2 ± 1575.71.14 ± 0.16
    ARL−/Y41.07 ± 3.18*60,608.8 ± 11,802.8*72.919.77.53,188.5 ± 594.3*1.06 ± 0.18
40 weeks
    ARX/Y35.46 ± 2.9178,210.5 ± 23,996.367.421.411.23,497.7 ± 667.21.50 ± 0.24
    ARL−/Y56.50 ± 7.83*41,480.6 ± 7,164.4*81.813.94.21,532.8 ± 409.5*1.32 ± 0.43
  • *P < 0.01 compared with ARX/Y (wild-type controls), n = 6. ∇, rearing: mouse stands up on its hind legs. RT, resting: speed <2.00 cm/s; MS, moving slowly: speed between 2.00 and 5.00 cm/s; MF, moving fast: speed >5.00 cm/s.