TABLE 1

Accelerated diabetes after transfer of purified, diabetogenic T-cells

No transfer3 × 106 cells5 × 106 cells10 × 106 cells23 × 106 cells
Diabetes incidence455 of 491 (93)18 of 18 (100)30 of 30 (100)32 of 34 (94)3 of 3 (100)
Median age (days) at diabetes onset76 (72–81)*58 (56–61)52 (50–54)50 (46–53)§47
  • Data are n (%) or median (interquartile range) and were pooled from 14 experiments.

  • *

    * P < 0.0001 vs. 3, 5, 10, and 23 × 106 cells;

  • P < 0.0004 vs. 5 × 106 cells, P < 0.0023 vs. 10 × 106 cells, and P < 0.0001 vs. 23 × 106 cells;

  • P < 0.0001 vs. 23 × 106 cells, but NS vs. 10 × 106 cells;

  • §

    § NS vs. 23 × 106 cells.