TABLE 2

Prevention of accelerated diabetes by prior transfer of pure CD4+ T cells

GroupDiabetogenic T-cells (×106)Protective CD4+ T-cells (×106)RatsRats rendered diabetic before age 120 daysDegree of protection against diabetes (%)Age at diabetes onset (days)
1A5None12120*52 (49–53)
1BNone43100100
1C5431119182
1D521.520100
2A3None1010058 (58–59)
2B321.530100
2C3106183109
  • Data are median (interquartile range) unless otherwise indicated. DP-BB rats (age 32–35 days) received CD4+ T-cells in the indicated amounts. After 4 days, diabetes-inducing T-cells were transferred in the indicated amounts. Data are pooled from four experiments.

  • *

    * P < 0.0001 vs. groups 1B and 1C, P < 0.0175 vs. group 1D;

  • P < 0.0045 vs. group 2B, P < 0.0003 vs. group 2C.