TABLE 3

Arterial plasma C-peptide levels and arterial plasma and hepatic sinusoidal glucagon levels in overnight-fasted, conscious dogs administered Exubera or matched IVC insulin infusion

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Arterial plasma C-peptide level (ng/ml)
    INH0.37 ± 0.070.19 ± 0.030.12 ± 0.020.09 ± 0.020.06 ± 0.020.06 ± 0.010.07 ± 0.020.08 ± 0.020.06 ± 0.020.06 ± 0.010.06 ± 0.010.07 ± 0.020.08 ± 0.02
    IVC0.52 ± 0.130.28 ± 0.080.14 ± 0.050.13 ± 0.040.08 ± 0.030.08 ± 0.020.09 ± 0.030.06 ± 0.020.06 ± 0.030.06 ± 0.030.06 ± 0.020.09 ± 0.040.06 ± 0.02
Arterial plasma glucagon level (pg/ml)
    INH40 ± 345 ± 342 ± 343 ± 341 ± 337 ± 235 ± 335 ± 232 ± 232 ± 329 ± 232 ± 232 ± 2
    IVC57 ± 661 ± 555 ± 357 ± 351 ± 447 ± 448 ± 338 ± 536 ± 538 ± 438 ± 437 ± 434 ± 3
Hepatic sinusoidal glucagon level (pg/ml)
    INH44 ± 444 ± 338 ± 237 ± 234 ± 229 ± 230 ± 328 ± 332 ± 331 ± 2
    IVC56 ± 750 ± 447 ± 342 ± 436 ± 436 ± 339 ± 438 ± 439 ± 333 ± 4
  • Data are means ± SE. INH group, n = 13; IVC group, n = 9. Time points are in minutes.