TABLE 6

Arterial blood lactate, alanine, and glycerol levels and net hepatic balance in overnight-fasted conscious dogs after Exubera administration or matched Humulin IVC insulin infusion

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Blood lactate level (μmol/l)
    INH1,102 ± 90939 ± 138837 ± 114834 ± 102814 ± 125620 ± 126479 ± 80478 ± 57472 ± 62
    IVC1,198 ± 1981,095 ± 234990 ± 180771 ± 109689 ± 98576 ± 109552 ± 89546 ± 84570 ± 80
Net hepatic lactate balance (μ/mol · kg−1 · min−1)
    INH7.20 ± 2.417.11 ± 2.1211.00 ± 1.997.24 ± 1.914.81 ± 2.060.28 ± 1.65*0.59 ± 2.400.15 ± 1.88−2.58 ± 1.26
    IVC5.76 ± 2.127.47 ± 1.389.49 ± 2.819.40 ± 2.696.03 ± 2.265.89 ± 1.881.47 ± 1.441.17 ± 1.55−1.71 ± 1.54
Blood alanine level (μmol/l)
    INH405 ± 20376 ± 21330 ± 20283 ± 18248 ± 15214 ± 16*220 ± 14*248 ± 17*270 ± 21*
    IVC372 ± 20362 ± 28356 ± 33299 ± 22274 ± 24282 ± 29321 ± 33316 ± 30338 ± 35
Net hepatic alanine balance (μmol · kg−1 · min−1)
    INH−1.29 ± 0.25−2.13 ± 0.47−1.63 ± 0.26*−2.01 ± 0.27−1.63 ± 0.34−2.05 ± 0.23−1.75 ± 0.38−1.42 ± 0.26−1.33 ± 0.48
    IVC−1.44 ± 0.27−1.56 ± 0.22−2.82 ± 0.66−2.14 ± 0.27−1.88 ± 0.42−1.67 ± 0.22−2.10 ± 0.32−1.93 ± 0.38−2.59 ± 0.43
Blood glycerol level (μmol/l)
    INH21 ± 329 ± 519 ± 331 ± 640 ± 1158 ± 962 ± 1078 ± 1287 ± 11
    IVC35 ± 820 ± 716 ± 516 ± 322 ± 442 ± 868 ± 663 ± 881 ± 9
Net hepatic glycerol balance (μmol · kg−1 · min−1)
    INH−0.33 ± 0.07−0.65 ± 0.19−0.30 ± 0.10−0.86 ± 0.32−0.78 ± 0.22−1.45 ± 0.41−1.24 ± 0.18−1.68 ± 0.32−1.87 ± 0.22
    IVC−0.54 ± 0.17−0.41 ± 0.17−0.23 ± 0.17−0.31 ± 0.08−0.34 ± 0.14−0.88 ± 0.24−1.38 ± 0.15−1.30 ± 0.25−1.75 ± 0.29
  • Data are means ± SE. Time points are in minutes.

  • *

    * P < 0.05 for INH vs. IVC. Balance >0 indicates net output and <0 indicates net uptake. INH group, n = 13; IVC group, n = 9.