TABLE 3

Association of SNPs in the ELMO1 with DN

PositionGenotype (2×3)AlleleMajor/major vs. othersMinor/minor vs. others
Intron 16+101856 (A/G)
    χ211.57.33.310.5
    P0.0030.0070.070.001
Intron 16+104353 (A/G)
    χ213.75.30.913.7
    P0.0010.020.30.0002
Intron 16+105608 (C/T)
    χ213.08.74.511.3
    P0.0020.0030.030.0008
Intron 16+114454 (C/T)
    χ210.14.20.810.1
    P0.0060.040.40.002
Intron 17+5495 (A/G)
    χ217.78.42.317.5
    P0.00010.0040.130.00002
Intron 18+9170 (A/G)*
    χ219.99.41.819.9
    P0.000050.0020.20.000008
Intron 19+2430 (G/A)
    χ216.69.83.016.2
    P0.00030.0020.080.00006
Intron 20+1239 (A/G)
    χ212.34.00.512.3
    P0.0020.040.50.0005
3′flanking + 735 (A/T)
    χ210.13.60.610.1
    P0.0060.060.40.001
Intron 1+5853 (T/G)
    χ27.43.40.77.4
    P0.020.070.40.007
OR (95% CI)
AlleleMajor/major vs.Minor/minor vs.
Intron 16+101856 (A/G)1.32 (1.08–1.62)1.26 (0.98–1.62)2.71 (1.45–5.05)
Intron 16+104353 (A/G)1.25 (1.03–1.51)1.13 (0.88–1.44)2.61 (1.55–4.41)
Intron 16+105608 (C/T)1.38 (1.11–1.70)1.32 (1.02–1.69)3.47 (1.61–7.49)
Intron 16+114454 (C/T)1.23 (1.01–1.50)1.13 (0.86–1.47)2.24 (1.35–3.73)
Intron 17+5495 (A/G)1.33 (1.10–1.61)1.21 (0.94–1.54)3.13 (1.79–5.47)
Intron 18+9170 (A/G)*1.32 (1.11–1.60)1.19 (0.92–1.52)2.67 (1.71–4.16)
Intron 19+2430 (G/A)1.34 (1.12–1.61)1.25 (0.97–1.60)2.46 (1.57–3.84)
Intron 20+1239 (A/G)1.22 (1.00–1.48)1.10 (0.80–1.41)2.59 (1.50–4.50)
3′flanking + 735 (A/T)1.21 (0.99–1.47)1.10 (0.86–1.41)2.41 (1.38–4.19)
Intron 1+5853 (T/G)0.83 (0.70–1.01)0.90 (0.71–1.16)0.57 (0.38–0.86)
  • *

    * Landmark SNP used for the genome-wide screening.