TABLE 2

Allele frequency for African-American type 2 diabetic subjects

PolymorphismMajor/minor alleleMinor allele frequency
Age- and sex-adjusted P value*
Type 2 diabetes (n = 185)Control (n = 149)
Cys7Gly (exon 1)T/G0.32 (0.27–0.37)0.45 (0.39–0.51)0.001
Leu44Phe (exon 2)C/T0.09 (0.06–0.12)0.10 (0.07–0.14)0.49
Leu124Met (exon 4)T/A0.22 (0.18–0.26)0.24 (0.19–0.29)0.68
5′UT G-233CG/C0.42 (0.36–0.47)0.46 (0.40–0.52)0.08
5′UT A-226GA/G0.25 (0.20–0.30)0.20 (0.15- 0.25)0.14
Intron 2 T-31CC/T0.32 (0.27–0.37)0.29 (0.24–0.35)0.55
Intron 4 C-4TC/T0.23 (0.19–0.28)0.23 (0.18- 0.28)0.71
  • Data are means (95% CI).

  • *

    * P value for genotype effect obtained from logistic regression assuming additive genetic model.