TABLE 3

Allele frequency for Caucasian type 2 diabetic subjects

PolymorphismMajor/minor alleleMinor allele frequency
Age- and sex-adjusted P value*
Type 2 diabetes (n = 144)Control (n = 282)
Cys7Gly (exon 1)T/G0.13 (0.09–0.18)0.15 (0.12–0.18)0.74
Leu44Phe (exon 2)C/T0.0 (0.0–0.02)0.002 (0.0–0.01)
Leu124Met (exon 4)T/A0.29 (0.24–0.34)0.31 (0.27–0.35)0.58
5′UT G-233CG/C0.17 (0.12–0.23)0.15 (0.12–0.18)0.09
5′UT A-226GA/G0.37 (0.31–0.43)0.34 (0.30–0.38)0.35
Intron 2 T-31CC/T0.42 (0.36–0.48)0.41 (0.38–0.45)0.74
Intron 4 C-4TC/T0.28 (0.23–0.34)0.29 (0.25–0.33)0.71
  • Data are means (95% CI).

  • *

    * P value for genotype effect obtained from logistic regression assuming additive genetic model.