TABLE 1

General characteristics of South Asians living in Chennai

Nondiabetic subjects
Diabetic subjects
ENPP1 wild typeENPP1 121QENPP1 wild typeENPP1 121Q
n (M/F)344 (112/232)112 (49/63)148 (64/84)75 (36/39)
Age (years)44 ± 1544 ± 1641 ± 643 ± 5
BMI (kg/m2)24 ± 523 ± 526 ± 5*25 ± 4
Systolic BP (mmHg)122 ± 18119 ± 14124 ± 16120 ± 17
Diastolic BP (mmHg)77 ± 1174 ± 1079 ± 1076 ± 11
Total cholesterol (mg/dl)184 ± 39179 ± 38198 ± 41207 ± 47
LDL cholesterol (mg/dl)116 ± 33112 ± 33118 ± 38125 ± 39
HDL cholesterol (mg/dl)45 ± 1045 ± 1143 ± 944 ± 9
Triglycerides (mg/dl)115 ± 62113 ± 61184 ± 162*193 ± 195*
Fasting glucose (mg/dl)85 ± 985 ± 9162 ± 63*180 ± 77*
HOMA-IR1.9 ± 1.31.6 ± 0.9NANA
  • Data are means ± SD unless otherwise specified. P values were determined using ANOVA for multiple comparisons of means.

  • *

    * P < 0.05 for mean difference with the subgroup of nondiabetic subjects with wild-type ENPP1.

  • P < 0.05 for mean difference with the subgroup of nondiabetic subjects with ENPP1 K121Q variant. BP, blood pressure.