TABLE 2

Pharmacokinetic parameters for pramlintide after injection of 30 or 45 μg i.p.

ParameterAll dose levels30 μg (n = 2)45 μg (n = 6)
Clearance (l · min−1 · kg−1)0.0553 ± 0.03
Volume of distribution (l/kg)2.2 ± 0.3
t1/2α (min)*34 ± 6
t1/2β (min)†33 ± 10
AUC (pmol · min/l)6,040 ± 2,2194,159 ± 406
  • Data are the means ± SE. *Patients with two-compartment best fit (n = 3); †patients with one-compartment best fit (n = 5).