TABLE 1

Association of DCCT baseline variables with ACE polymorphisms

Variable GenotypesnACE polymorphisms
rs1800764
PInsertion/deletion
Prs9896208
P
CCCTTTIIIDDDCCCTTT
Total cohort1,365258698409316680369560612193
Sex
    Male7171263742170.411683641850.562963151060.69
    Female64813232419214831618426429787
DCCT treatment
    Intensive6711243322150.251633371710.38294286910.12
    Conventional694134366194153343198266326102
Cohort
    Primary6861343472050.821513511840.52279312950.88
    Secondary67912435120416532918528130098
Use of ACE inhibitors during EDIC
    Yes408682301100.030902081100.77167185560.87
    No885176429280210435240364391130
Age at diagnosis (years)1,36520.8 ± 7.921.5 ± 8.121.0 ± 8.20.4120.9 ± 8.321.5 ± 8.121.0 ± 7.90.4321.1 ± 8.121.3 ± 8.121.3 ± 7.70.66
Age at baseline (years)1,36526.3 ± 7.027.1 ± 7.026.7 ± 7.30.3326.7 ± 7.326.9 ± 7.126.7 ± 6.90.9226.8 ± 7.226.8 ± 7.027.0 ± 7.10.86
Type 1 diabetes duration (years)1,3655.5 ± 4.15.6 ± 4.25.7 ± 4.20.805.9 ± 4.25.5 ± 4.15.7 ± 4.20.285.8 ± 4.25.4 ± 4.25.8 ± 4.10.20
HbA1c at eligibility (%)1,3659.0 ± 1.69.0 ± 1.69.1 ± 1.60.469.1 ± 1.69.0 ± 1.69.0 ± 1.60.699.1 ± 1.59.0 ± 1.79.0 ± 1.60.50
BMI (kg/m2)1,36522.9 ± 2.723.5 ± 2.823.5 ± 2.80.0123.5 ± 2.923.5 ± 2.823.1 ± 2.70.0223.4 ± 2.923.4 ± 2.723.2 ± 2.80.77
Mean arterial pressure (mmHg)1,36586 ± 987 ± 986 ± 80.7087 ± 886 ± 986 ± 90.9587 ± 986 ± 987 ± 90.44
Total cholesterol (mg/dl)1,365178 ± 34176 ± 33176 ± 340.90175 ± 34177 ± 33176 ± 330.67177 ± 33175 ± 33178 ± 340.84
HDL cholesterol (mg/dl)1,36552 ± 1350 ± 1249 ± 110.1249 ± 1150 ± 1251 ± 130.1550 ± 1250 ± 1251 ± 120.45
Triglycerides (mg/dl)1,36579 ± 4080 ± 4287 ± 610.1689 ± 6778 ± 3682 ± 480.0684 ± 5680 ± 3880 ± 500.27
AER (μg/min)1,36510 ± 1010 ± 1212 ± 150.7812 ± 1510 ± 1210 ± 100.0512 ± 1410 ± 1010 ± 170.30
  • Data are means± SD. χ2 P values are reported for categorical traits; other values are Kruskal-Wallis P values. The following variables were Ln transformed to normalize the data for statistical analysis: eligibility HbA1c, total cholesterol, HDL cholesterol, triglycerides, and AER.