TABLE 2

Univariate proportional hazards analysis of ACE genotype and haplotype with renal outcomes

ACE genotype			Grades of diabetic nephropathy
ACE genotype				Persistent microalbuminuria (n = 246)				Severe nephropathy (n = 115)
Single locus	Genotype comparisons	HR	95% CI	Wald P value	HR	95% CI	Wald P value
rs1800764	CC vs. CT	0.94	0.68–1.32	0.74	0.67	0.39–1.15	0.15
	TT vs. CT	0.64	0.47–0.88	0.006*	0.70	0.45–1.10	0.12
Insertion/deletion	DD vs. DI	1.02	0.76–1.37	0.87	0.96	0.62–1.48	0.86
	II vs. DI	0.67	0.47–0.95	0.026*	0.69	0.41–1.15	0.15
rs9896208	TT vs. CT	1.09	0.76–1.56	0.63	0.96	0.57–1.61	0.88
	CC vs. CT	0.70	0.53–0.93	0.015*	0.60	0.39–0.92	0.020*
Haplotype
rs1800764, insertion/ deletion, rs9896208
CDT/CDT		0.94	0.60–1.48	0.78	0.90	0.47–1.73	0.75
TIC/TIC		0.56	0.37–0.85	0.007*	0.53	0.29–0.97	0.04*
CDC/CDT		0.83	0.47–1.45	0.51	0.56	0.22–1.43	0.22
CDC/TIC		0.78	0.51–1.19	0.25	0.69	0.36–1.33	0.27
CDT/other		1.06	0.69–1.62	0.79	1.04	0.57–1.88	0.90
TIC/other		0.66	0.42–1.06	0.09	0.77	0.40–1.49	0.44
Other/other		0.71	0.34–1.49	0.36	0.54	0.16–1.76	0.30

Each model was adjusted for study design (treatment, cohort, cohort by treatment interaction, and stratified by year of entry into DCCT). Indicated haplotypes are compared with the most frequent haplotype pair (CDT/TIC).
*
* P < 0.05.