TABLE 1

Plasma measurements in the basal state and during euglycemic-hyperinsulinemic clamps

Normal diet
HF diet
Adv-LacZAdv-AdipoAdv-LacZAdv-Adipo
Body weight (g)292.2 ± 4.8289.4 ± 4.4384.1 ± 12.8402.1 ± 11.8
Basal (n)171899
    Glucose (mg/dl)129.7 ± 3.5124.6 ± 4.9133.9 ± 4.7129.6 ± 4.0
    Insulin (ng/ml)0.73 ± 0.050.75 ± 0.041.07 ± 0.06*0.84 ± 0.06
    FFA (mmol/l)1.09 ± 0.141.17 ± 0.091.19 ± 0.161.25 ± 0.12
    Resistin (ng/ml)3.5 ± 0.33.0 ± 0.4NDND
    Leptin (ng/ml)7.7 ± 3.18.1 ± 1.8NDND
    Liver function
        Aspartate aminotransferase (IU)35.4 ± 1.532.4 ± 0.756.4 ± 2.554.8 ± 3.8
        Alanine aminotransferase (IU)38.2 ± 1.335.2 ± 0.844.4 ± 2.444.0 ± 2.5
Clamp
    Maximal insulin (n)101099
        Glucose (mg/dl)151.1 ± 0.6151.0 ± 0.9148.8 ± 1.2151.1 ± 1.3
        Insulin (ng/ml)25.22 ± 1.1024.77 ± 1.0924.32 ± 3.2724.45 ± 0.90
        FFA (mmol/l)0.08 ± 0.020.07 ± 0.020.08 ± 0.010.08 ± 0.01
    Submaximal insulin (n)78
        Glucose (mg/dl)150.3 ± 1.6151.4 ± 1.9NDND
        Insulin (ng/ml)3.52 ± 0.163.49 ± 0.16NDND
        FFA (mmol/l)0.38 ± 0.060.32 ± 0.05NDND
  • Data are means ± SE.

  • *

    * P < 0.05. ND, not determined.