TABLE 1

Changes in plasma concentrations of glucose, FFA, and insulin after NE or insulin injection

WT
KO
0 min11 min0 min11 min
Plasma glucose (mg/dl)
    Vehicle127 ± 12122 ± 9113 ± 7113 ± 7
    NE121 ± 16155 ± 10*119 ± 12171 ± 24*
    Insulin118 ± 689 ± 4*115 ± 889 ± 10*
Plasma FFA (μEq/l)
    Vehicle885 ± 100734 ± 23924 ± 153804 ± 87
    NE1,076 ± 131,231 ± 37*955 ± 1501,211 ± 67
    Insulin1,107 ± 82645 ± 29*951 ± 69618 ± 59*
Plasma insulin (ng/ml)
    Vehicle0.33 ± 0.040.27 ± 0.080.26 ± 0.060.21 ± 0.04
    NE0.32 ± 0.020.25 ± 0.050.23 ± 0.020.22 ± 0.10
    Insulin0.22 ± 0.063.27 ± 0.65*0.22 ± 0.103.62 ± 0.54*

  • Data are means ± SE for 3 mice. WT and UCP1-KO mice were fasted overnight, anesthetized, and injected with 0.2 mg/kg NE, 1.0 unit/kg insulin, or saline intraperitoneally as vehicle as in Fig. 2. The concentration of plasma glucose, FFA, and insulin were measured before and 11 min after the injection.

  • *

    * P < 0.05 vs. 0 min.