TABLE 1

Cytokines produced by CD4+CD25+ or CD4+CD25 T-cells from 6-week-old or diabetic NOD mice

CD25+ 6 weeksCD25 6 weeksCD25+ diabeticCD25 diabetic
IL-4 (pg/ml)13.111.912.121.2
IL-10 (pg/ml)116.224.468.361.6
IFN-γ (pg/ml)342.7*593.61,226.8*2,788.3
TGF-β (pg/ml)133.1*106.245.4126.7
  • CD4+CD25+ or CD4+CD25 T-cells from 6-week-old or diabetic mice were stimulated with CD3 antibody and APCs. Single-cell cultures were performed, and supernatants were recovered 24, 48, and 72 h later.

  • *

    * P < 0.05 for comparisons between cell subsets.

  • P < 0.05 for comparisons between cell subsets.

  • P < 0.05 for comparisons between cell subsets.