TABLE 2

Pretreatment (days 1–6) balance of nine elements with corresponding urinary and fecal outputs in diabetic and matched control subjects

ControlDiabeticP
Cu (μmol/6 days)
    Balance1.49 (−25.0 to 28.0)23.7 (0.9–46.4)0.19
    Urinary1.16 (1.04–1.28)1.59 (1.36–1.82)0.0011
    Fecal168 (143–193)159 (139–180)NS
Fe (μmol/6 days)
    Balance480 (180–779.4)479.2 (189.4–769.1)NS
    Urinary2.13 (1.81–2.46)3.61 (2.98–4.25)0.0001
    Fecal1,757 (1,481–2,033)1,888 (1,624–2,153)NS
Zn (μmol/6 days)
    Balance−167.2 (−383.8 to 49.4)−71.8 (−232.8 to 89.2)NS
    Urinary50.4 (41.2–59.5)125.7 (106.4–145.1)<0.0001
    Fecal1,420 (1,212–1,628)1,301 (1,134–1,469)NS
Mn (μmol/6 days)
    Balance−45.7 (−188 to 97.0)90.0 (−35.7 to 218)NS
    Urinary0.03 (0.0–0.05)0.14 (0.07–0.21)0.0016*
    Fecal958 (810–1,106)889 (770–1,007)NS
Mo (μmol/6 days)
    Balance1.03 (−0.84 to 2.89)2.87 (1.65–4.08)0.092
    Urinary3.89 (3.05–4.72)3.51 (2.70–4.33)NS
    Fecal6.40 (5.22–7.57)5.41 (4.32–6.50)NS
Ca (mmol/6 days)
    Balance15.2 (−7.4 to 46.3)39.2 (14.4–64.0)NS
    Urinary21.8 (18.5–25.2)29.3 (22.8–35.8)0.038
    Fecal159.5 (135.4–183.7)141.9 (119.8–164.1)NS
Mg (mmol/6 days)
    Balance−0.28 (−13.3 to 12.7)10.8 (−3.3 to 24.9)NS
    Urinary31.0 (26.7–35.3)29.0 (25.3–32.6)NS
    Fecal83.1 (71.5–94.8)92.3 (76.7–101.6)NS
Se (μmol/6 days)
    Balance−0.66 (−1.48 to 0.15)−0.84 (−1.82 to 0.15)NS
    Urinary2.07 (1.69–2.45)2.74 (2.32–3.16)0.018
    Fecal3.30 (2.66–3.94)2.19 (1.79–2.59)NS
Cr (μmol/6 days)
    Balance2.26 (1.58–2.95)2.61 (1.88–3.35)NS
    Urinary0.00 (0.00–0.00)0.012 (0.002–0.022)0.018*
    Fecal2.82 (2.23–3.42)2.90 (2.50–3.30)NS
  • Data are means (95% CI). There were 20 subjects each in the diabetic and control groups. P was determined with a one-way ANOVA (two-tailed tests).

  • *

    * Urinary Mn and Cr were near their respective minimum detectable concentrations, so these results should be interpreted with caution.