TABLE 3

Effects of trientine treatment on differences in balance and in urinary and fecal excretion of Cu, Fe, Zn, Mn, Ca, and Se in control and diabetic subjects

Overall model
Factor tests
Control/diabetes
Placebo/trientine
Interaction
F3,36PF1,36PF1,36PF1,36P
Cu
    Balance3.610.0220.04NS0.50NS10.280.0028
    Urinary excretion37.74<0.00013.490.07106.36<0.00013.370.075
    Fecal excretion4.050.0140.24NS2.09NS9.820.0034
Fe
    Balance2.02NS0.09NS5.250.0280.71NS
    Urinary excretion1.92NS0.23NS2.09NS3.430.072
    Fecal excretion2.340.0900.04NS6.060.0190.91NS
Zn
    Balance7.370.00060.00NS11.010.002111.100.002
    Urinary excretion27.14<0.00014.140.04973.62<0.00013.660.064
    Fecal excretion11.76<0.00020.07NS26.02<0.00019.190.0045
Mn
    Balance3.240.0330.10NS5.220.0284.400.043
    Urinary excretion0.84NS2.30NS0.00NS0.23NS
    Fecal excretion3.750.0190.17NS6.240.0174.850.034
Ca
    Balance5.250.00420.00NS10.840.00224.900.033
    Urinary excretion0.60NS0.82NS0.32NS0.67NS
    Fecal excretion5.970.00210.08NS11.960.00145.880.020
Se
    Balance3.990.0154.470.0411.06NS6.440.016
    Urinary excretion1.41NS2.77NS0.10NS1.35NS
    Fecal excretion3.740.0191.80NS2.51NS6.910.013
  • Values determined with two-way ANOVA. Models were fitted by restricted maximum likelihood. No significant effects on Mo, Mg, or Cr were present, so their values have not been included. In the overall model, we excluded from analysis the one control subject who did not complete the treatment aspect of the study.